PARACETAMOL DEPLETES GLUTATHIONE Natural Healing Centre Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem A study published in Gastroenterology describes a new mitochondrial mediator in the hepatotoxicity induced by paracetamol. Institute of Biomedical Research of Barcelona Frontiers Commentary: Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Good ol' paracetamol: 'But an overconsumption takes its toll' Journal of Anaesthesia Practice